Labetalol 10 mg IV to 20 mg IV over 1 to 2 minutes, may repeat once
or
Nitropaste
or
Nicardipine infusion 5 mg/hr IV, titrate up by 2.5 mg/hr at 5-15 minute intervals, maximum dose 15 mg/hr, when desired blood pressure is attained, reduce to 3 mg/hr.
Although you can go directly to nicardipine before giving tPA, once tPA has started, generally do not use nicardipine unless labetalol has failed or systolic blood pressure > 230 or diastolic blood pressure > 121.